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KMID : 0613820090190050664
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Journal of Life Science
2009 Volume.19 No. 5 p.664 ~ p.670
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Association of β3-Adrenergic Receptor Polymorphisms and High-Density Lipoprotein Cholesterol
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Yu Byeng-Chul
Jeon Man-Joong
Lee Yong-Hwan
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Abstract
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The β₃-adrenergic receptor (ADRB3) is expressed mainly in visceral adipose tissue and is thought to contribute to lipolysis and the delivery of free fatty acids to the portal vein. This study was aimed at evaluating the association between high-density lipoprotein cholesterol (HDL-C) and ADRB3 genetic polymophisms. A total of 991 healthy examinees who were examined in a university hospital, located in Busan City, between May and December 2006 were enrolled in this study. Height, weight, body mass index, waist circumference, and systolic and diastolic blood pressures of the subjects were examined. Intravenous concentrations of fasting blood glucose, total cholesterol, HDL-C, low-density lipoprotein cholesterol, and triglyceride were also measured. After extracting DNA from the subjects, mutations of the +188T＞C (Trp64Arg) of exon 1 and +3893T＞C of intron 2 on the ADRB3 gene were genotyped using the single base extension method. We have identified a novel mutation of ADRB3 that is located in intron 2. The frequency of its minor allele was 0.164. Both the +188T＞C mutation of exon 1 and +3893T＞C mutation of intron 2 were significantly associated with HDL-C. The mean concentration of serum HDL-C was significantly lower in the presence of their minor allele ’C’. These results suggest that both mutations of +188T＞C of exon 1 and +3895T＞C of intron 2 have significant associations with HDL-C in the Korean population.
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KEYWORD
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ADRB3 gene, high-density lipoprotein cholesterol, polymorphism
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